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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEK
All Species:
17.27
Human Site:
S309
Identified Species:
38
UniProt:
P08567
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08567
NP_002655.2
350
40097
S309
S
N
S
N
G
R
K
S
E
E
E
N
L
F
E
Chimpanzee
Pan troglodytes
XP_515524
350
40124
S309
S
N
S
N
G
R
K
S
E
E
E
N
L
F
E
Rhesus Macaque
Macaca mulatta
XP_001094492
350
40060
S309
S
N
S
N
G
R
K
S
E
E
E
N
L
F
E
Dog
Lupus familis
XP_537486
375
42096
V335
D
N
G
V
P
T
G
V
K
G
N
V
Q
G
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHK5
350
39882
S309
S
S
H
D
V
K
K
S
D
E
E
N
L
F
E
Rat
Rattus norvegicus
Q4KM33
350
39977
S309
S
N
P
D
G
K
K
S
D
E
E
N
L
F
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512767
334
37917
N293
D
S
P
D
A
K
K
N
E
D
G
N
L
F
E
Chicken
Gallus gallus
NP_990194
353
40280
D312
M
P
D
S
K
K
Y
D
V
E
N
N
L
F
E
Frog
Xenopus laevis
NP_001080021
289
33430
Q249
F
R
G
N
V
V
K
Q
G
C
L
L
K
Q
G
Zebra Danio
Brachydanio rerio
NP_957135
352
40176
E311
V
P
D
A
K
R
H
E
V
D
G
N
L
F
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781827
375
42698
K333
S
D
V
T
V
K
N
K
N
R
Q
N
L
F
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
36
N.A.
92
92
N.A.
80.5
81.5
63.1
67.3
N.A.
N.A.
N.A.
N.A.
34.4
Protein Similarity:
100
100
100
55.7
N.A.
96.8
97.1
N.A.
89.4
90.6
73.7
83.8
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Identity:
100
100
100
6.6
N.A.
60
73.3
N.A.
40
33.3
13.3
33.3
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
13.3
N.A.
86.6
93.3
N.A.
73.3
46.6
13.3
40
N.A.
N.A.
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
19
10
19
28
0
0
0
10
19
19
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
37
55
46
0
0
0
73
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
82
0
% F
% Gly:
0
0
19
0
37
0
10
0
10
10
19
0
0
10
10
% G
% His:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
19
46
64
10
10
0
0
0
10
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
10
10
82
0
0
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
46
0
37
0
0
10
10
10
0
19
82
0
0
10
% N
% Pro:
0
19
19
0
10
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
10
0
0
10
0
10
10
0
% Q
% Arg:
0
10
0
0
0
37
0
0
0
10
0
0
0
0
0
% R
% Ser:
55
19
28
10
0
0
0
46
0
0
0
0
0
0
10
% S
% Thr:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
0
% T
% Val:
10
0
10
10
28
10
0
10
19
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _